Yup,that was a usual question that faced by medical practitioner and also by patient that has it. Patient usually comes to emergency room (ER) with symptom nausea, vomiting, malaise, dehidrate mild or severe, could be jaundice in chronic or acute condition, high blood pressure, headache, etc. But the primary symptom usually vomiting that made the patient dehidration and can directly make the family as the reason to bring him to the ER in the hospital.
The disease that have relation with the increse of SGOT and SGPT are hepatitis can be viral or non viral, fatty liver, gall stone, cholecystitis, cholelithiasis, malignancy, etc. all the disease can be figure out by seeing the symptom firstly. Next to confirm the diagnosis usually doctor needs to do physical examination, may be he can find hepatomegaly, spleenomegaly, or other sign that support the diagnosis. Furthermore he will have laboratory result to compare the differential diagnosis to confirm the final diagnosis.
SGOT is usually a marker for chronic liver disease. SGOT is an enzyme that located in heart muscle, smooth muscle, liver cells, etc. SGPT is usually as a marker for acute liver disease. SGPT only located in liver cells. So if the ratio of SGOT to SGPT is high, we need pay attention that it can be chronic liver disease. And than so does otherwise if ratio SGPT to SGOT is high.
In this era, the higher rates according my opinion is fatty liver. Because nowadays people are less to do sport and like to eat fastfood, while on fastfood there were high cholesterol and if body difficult to convert it. The cholesterol will circulate around your body through the blood. So on the lab test the lipid profile show high level (high LDL, trygliseride,and total cholesterol.but low HDL). LDL was bad cholesterol, while HDL is a good cholesterol. If the cholesterol to much in our body it can be deposit through all your body but if the lipid deposit in your liver it can cause fatty liver. Fatty liver is a condition where the surface and inside your liver cover by lipid. Sometimes lipid can kill the healthy liver cell, so that makes lab test for SGOT and SGPT increased.
The therapy for fatty liver actually first to have diet. To maintain the condition patient used to have sport, mild sport. Because patient have weak condition and they can`t be force to do heavy sport. If they do heavy sport it will make patient condition deteriorate.
So keep healthy by diet, sport and eat healthy food. Avoid to eat fastfood or junk food. (©Ajib 2009)